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The Phase 2 trial also included a meta-analysis benchmark: a 2025 systematic review and meta-analysis of 3 RCTs involving 878 patients found a mean body weight reduction of −14.33% versus placebo, with a BMI reduction of −5.38 and waist circumference reduction of −10.51 cm
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As an example, the results of a meta-analysis evaluating the risk of cardiorenal effects exerted by GLP-1RAs and SGLT2is evidenced similar benefits (about 12–14% risk reduction), although GLP-1RAs are superior for stroke risk reduction [142]
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